On the third Thursday evening in September of each year, Yukon 66 Main Street hosts Cruisers at the annual "Cruise-In for a Cause" under the lights of Main.

This is a free Cruise with participants encouraged to contribute to one of the participating local causes.  

Cruise-In for a Cause is an open Cruise on Yukon's iconic Route 66. In addition to the thrill of enjoying America's Main Street in a fun and unique way, car enthusiasts will have the opportunity to support local charitable causes. The event is free and open to anyone to cruise throughout the evening. A limited number of reserved "Park & Show" spaces in Main Street's 400 block will be available by registration.

The Y66MSA board selects a non-profit organization to be the participating "Help" Cause to benefit from contributions collected through Park & Show registrations, direct donations, and collections at the donation stations during the event.